Vesugen Research Information
Vascular Support Tetrapeptide
AEDL Tetrapeptide Bioregulator for Vascular Research
Important: This information is for educational and research purposes only. Always consult with a qualified healthcare professional before use.
Contents
What is Vesugen?
Vesugen is a synthetic tetrapeptide bioregulator with the amino acid sequence Ala-Glu-Asp-Leu (AEDL). It is part of the Khavinson peptide bioregulator family, initially isolated from vascular tissue .
Vesugen has emerged as a promising molecular tool for investigating vascular function, angiogenesis, and tissue repair in research models .
Mechanism of Action
Vesugen functions through multiple pathways to support vascular research models:
DNA Interaction
Penetrates cell nuclei and binds to specific DNA sequences, modulating gene transcription
Vascular Cell Regulation
Regulates vascular cell function and tissue homeostasis
Epigenetic Effects
Modulates chromatin structure and gene expression patterns in vascular tissue
Vesugen demonstrates tissue-specific regulatory activity on vascular cells, modulating gene expression and cellular function through DNA interaction and epigenetic mechanisms .
Research Applications
Vascular Research
Vascular function, angiogenesis, endothelial cell studies
Tissue Repair
Wound healing, tissue regeneration, blood flow studies
Cellular Aging
Age-related vascular changes, endothelial senescence
Epigenetic Studies
Gene expression regulation, chromatin remodeling in vascular tissue
Clinical Studies
Key Research Findings:
- Vesugen demonstrates tissue-specific regulatory activity on vascular cells
- Modulates gene expression in vascular tissue models
- Part of the Khavinson peptide bioregulator system targeting vascular tissues
- Promotes vascular tissue homeostasis through epigenetic mechanisms
Dosing Guide
Reconstitute your freeze-dried vial with 3mL bacteriostatic water. Units assume a standard U-100 insulin syringe (100 units = 1 mL).
Step 1: Select Vial Size
Step 2: Select Dose
Research protocols typically range from 50-200 mcg daily via subcutaneous injection.
Vial Size
20mg Vial
Selected Dose
50 mcg
Doses per Vial
400 doses
Units on Syringe
7.5 units
Volume
0.075 mL
Protocol
Starting
Recommended Schedule
Once daily - Subcutaneous Injection
Do not change your dose unless advised by a qualified professional.
Reconstitution Instructions
Add 3mL of bacteriostatic water to your freeze-dried vial and mix gently. After reconstitution, use the table below to draw your dose:
Vial Size
20mg vial with 3mL bac water (6.67 mg/mL)
| Dose | Units on Syringe | Volume (mL) | Protocol |
|---|
Always use a new sterile needle and syringe for each injection.
Safety & Precautions
Do not use if you:
- Are allergic to Vesugen or any components
- Are pregnant or breastfeeding
Warning: If you experience severe allergic reactions, difficulty breathing, or signs of anaphylaxis, seek immediate medical help.
References
- Khavinson VKh, et al. Peptide regulation of gene expression in vascular tissue. Bull Exp Biol Med. 2010
- Khavinson VKh, et al. Tissue-specific effects of short peptides on vascular function. Adv Gerontol. 2002
- Vesugen Research Overview. Peptide Sciences. 2025
This information is for educational and research purposes only. Always consult with a qualified healthcare professional.
Last updated: August 2026