PNC-27 Research Information
Anti-Cancer Peptide
p53-Activating Peptide for Cancer Research
Important: This information is for educational and research purposes only. Always consult with a qualified healthcare professional before use.
Contents
What is PNC-27?
PNC-27 is a synthetic peptide composed of a 12-amino acid sequence derived from the HDM-2 binding domain of p53, linked to a cell-penetrating peptide . It is designed to induce apoptosis in cancer cells while sparing normal cells .
PNC-27 has emerged as a promising molecular tool for investigating p53-mediated apoptosis, cancer cell targeting, and oncological research models .
Mechanism of Action
PNC-27 functions through multiple pathways to support cancer research models:
p53 Activation
Restores p53 tumor suppressor function in cancer cells
Apoptosis Induction
Triggers programmed cell death specifically in cancer cells
Cell Penetration
Crosses cell membranes to deliver p53 sequence intracellularly
PNC-27 demonstrates cancer-selective cytotoxicity, inducing apoptosis in cancer cells while leaving normal cells unaffected .
Research Applications
Cancer Research
p53 pathway studies, apoptosis mechanisms, cancer cell targeting
Drug Development
Peptide-based therapeutics, targeted cancer treatments
Cell Penetration Studies
Intracellular delivery mechanisms, cell-penetrating peptide research
Tumor Suppressor Research
p53 restoration, tumor suppression mechanisms
Clinical Studies
Key Research Findings:
- PNC-27 demonstrates cancer-selective cytotoxicity in preclinical studies
- Induces apoptosis in cancer cells through p53 pathway restoration
- Spares normal cells while targeting cancer cells
- Cell-penetrating peptide delivery enables intracellular targeting
Dosing Guide
Reconstitute your freeze-dried vial with 3mL bacteriostatic water. Units assume a standard U-100 insulin syringe (100 units = 1 mL).
Step 1: Select Vial Size
Step 2: Select Dose
Research protocols typically range from 250-500 mcg daily via subcutaneous injection.
Vial Size
5mg Vial
Selected Dose
250 mcg
Doses per Vial
20 doses
Units on Syringe
15 units
Volume
0.15 mL
Protocol
Standard
Recommended Schedule
Once daily - Subcutaneous Injection
Do not change your dose unless advised by a qualified professional.
Reconstitution Instructions
Add 3mL of bacteriostatic water to your freeze-dried vial and mix gently. After reconstitution, use the table below to draw your dose:
Vial Size
5mg vial with 3mL bac water (1.67 mg/mL)
| Dose | Units on Syringe | Volume (mL) | Protocol |
|---|
Always use a new sterile needle and syringe for each injection.
Safety & Precautions
Do not use if you:
- Are allergic to PNC-27 or any components
- Are pregnant or breastfeeding
Storage Instructions:
- Lyophilized: Store at -20°C (-4°F) long-term
- After reconstitution: Refrigerate at 2-8°C (35.6-46.4°F)
- Avoid freeze-thaw cycles after reconstitution
Warning: If you experience severe allergic reactions, difficulty breathing, or signs of anaphylaxis, seek immediate medical help.
References
- PNC-27 Research Overview. Peptide Sciences. 2025
- p53-Activating Peptide Research. My Peptide. 2025
This information is for educational and research purposes only. Always consult with a qualified healthcare professional.
Last updated: August 2026