IGF-OES Research Information
IGF-1 Ec Isoform E-Peptide
Mechano Growth Factor E-Peptide for Tissue Repair Research
Important: This information is for educational and research purposes only. Always consult with a qualified healthcare professional before use.
Contents
What is IGF-OES?
IGF-OES (IGF-1 Ec or Mechano Growth Factor E-peptide) is a peptide derived from the E-domain of the IGF-1 gene, produced by alternative splicing. The E-peptides are the C-terminal extensions of the pro-IGF-I molecule with a 24-amino acid sequence.
The IGF-1Ec isoform (MGF) has been mainly associated with muscle regeneration processes.
Mechanism of Action
IGF-OES functions through multiple pathways:
MAPK Pathway
E-peptides activate ERK1/2 phosphorylation without affecting Akt
IGF-IR Independent
Effects not mediated via IGF-1R, insulin receptor, or hybrid receptors
Apoptosis Inhibition
E-domain peptide inhibits intrinsic apoptotic pathway
E-peptides enhance IGF-I receptor activity by augmenting IGF-I signaling through the MAPK pathway.
Research Applications
Muscle Repair
Satellite cell activation and fusion, muscle regeneration studies
Cardiac Research
Preservation of cardiac function, inhibition of pathologic hypertrophy
Tendon Research
Tenocyte migration, tendon repair, FAK-ERK1/2 signaling
Cancer Research
Prostate cancer biology, tumor growth and progression studies
Clinical Studies
- IGF-1Ec expression significantly higher in prostate cancer tissues
- Expression correlates with tumor stage; higher expression in Stage III/IV
- MGF E peptide possesses mitogenic activity independent of IGF-1R
- E-peptide promotes cellular proliferation by activating ERK1/2 pathway
Dosing Guide
Reconstitute 0.1mg vial with 3mL bacteriostatic water = 0.033 mg/mL. Units assume a standard U-100 insulin syringe.
Step 1: Select Vial Size
Step 2: Select Dose
Vial Size
0.1mg Vial
Selected Dose
1 mcg
Doses per Vial
100 doses
Units on Syringe
3 units
Volume
0.03 mL
Protocol
Starting
Recommended Schedule
Once daily - Subcutaneous Injection
Do not change your dose unless advised by a qualified professional.
Reconstitution Instructions
Add 3mL of bacteriostatic water to your freeze-dried vial and mix gently.
Vial Size
0.1mg vial with 3mL bac water (0.033 mg/mL)
| Dose | Units | Volume (mL) | Protocol |
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Always use a new sterile needle and syringe for each injection.
Safety & Precautions
Do not use if: Allergic to IGF-OES, pregnant/breastfeeding, active cancer.
Warning: If you experience severe allergic reactions, difficulty breathing, or signs of anaphylaxis, seek immediate medical help.
References
- Armakolas A, et al. Preferential expression of IGF-1Ec (MGF) transcript in cancerous tissues. Prostate. 2010
- Armakolas A, et al. Oncogenic Role of the Ec Peptide. Mol Med. 2015
This information is for educational and research purposes only. Always consult with a qualified healthcare professional.
Last updated: August 2026