Cardiogen Research Information
Cardiovascular Support Peptide
Tetrapeptide Bioregulator for Cardiac Research
Important: This information is for educational and research purposes only. Always consult with a qualified healthcare professional before use.
Contents
What is Cardiogen?
Cardiogen is a short-chain tetrapeptide bioregulator with the amino acid sequence Ala-Glu-Asp-Arg (AEDR). It is a synthetic peptide compound with a molecular weight of 489 Da (C₁₈H₃₁N₇O₉).
Cardiogen is derived from research into short peptides with tissue-specific regulatory activity on cardiomyocytes and has emerged as a promising molecular tool for investigating cardiovascular biology, fibroblast activity, cardiomyocyte survival, and extracellular matrix dynamics in research models.
Mechanism of Action
Cardiogen functions through multiple pathways to support cardiac research models:
DNA Interaction
Modulates DNA hydrolysis and repair processes through interaction with endonucleases rather than direct DNA binding
Fibroblast Regulation
Stimulates fibroblast-driven synthesis of extracellular matrix components including collagen and elastin
Cardiomyocyte Protection
Downregulates pro-apoptotic mediators such as p53, supporting cell survival in stressed cardiomyocytes
Additionally, Cardiogen is believed to promote the proliferation of progenitor-like cells within cardiac tissues, supporting regenerative signaling and tissue remodeling pathways. It may also interact with cellular antioxidant pathways, potentially attenuating the accumulation of reactive oxygen species within cardiomyocytes.
Research Applications
Cardiovascular Biology
Investigating peptide-mediated signaling cascades in cardiac tissues and related cell types
Receptor Binding Studies
Quantitative characterization of peptide-receptor dynamics and binding kinetics
Ischemia-Reperfusion Research
Examining antioxidant and anti-apoptotic properties in hypoxic challenge models
Gene Expression Studies
Mapping downstream signaling cascades including MAPK pathways and Akt activation
Clinical Studies
Key Research Findings:
- Clinical research has demonstrated that Cardiogen peptides positively influence metabolic processes in myocardial cells
- Improved myocardial contractile function in patients with ischemic heart disease
- Enhanced exercise tolerance and normalized cardiovascular system parameters
- Increased effectiveness of complex treatment for coronary artery disease
- Research suggests potential for reducing scar formation and promoting regeneration in cardiac tissue repair models
Dosing Guide
Select your vial size and dose to see corresponding volume, clicks, dosing frequency, and doses per vial:
Step 1: Select Vial Size
Step 2: Select Dose
Vial Size
10mg Vial
Selected Dose
2 mg
Doses per Vial
5 doses
Clicks
60 clicks
Volume
0.60 mL
Protocol
Standard
Recommended Schedule
Daily - Research Protocol
Do not change your dose unless advised by a qualified professional.
Reconstitution Instructions
Add 3mL of bacteriostatic water to your freeze-dried vial and mix gently. After reconstitution, use the table below to draw your dose:
Vial Size
10mg vial with 3mL bac water
| Dose | Units on Syringe | Volume (mL) | Protocol |
|---|
Always use a new sterile needle and syringe for each injection.
Safety & Precautions
Do not use if you:
- Are allergic to Cardiogen or any components
- Are pregnant or breastfeeding
Adverse Effects:
- No adverse effects have been identified in clinical research
- Individual intolerance may occur in rare cases
Warning: If you experience severe allergic reactions, difficulty breathing, or signs of anaphylaxis, seek immediate medical help.
References
- Khavinson VKh, Fedoreyeva LI, Vanyushin BF. Site-specific binding of short peptides with DNA modulated eukaryotic endonuclease activity. Bull Exp Biol Med. 2011 May;151(1):66-70
- Fedoreyeva LI, Smirnova TA, Kolomijtseva GY, et al. Interaction of short peptides with FITC-labeled wheat histones and their complexes with deoxyribooligonucleotides. Biochemistry (Mosc). 2013 Feb;78(2):166-75
- Cardiogen Peptide Research Overview. NovoPro Bioscience
- Cardiogen Product Information. MedChemExpress
This information is for educational and research purposes only. Always consult with a qualified healthcare professional.
Last updated: August 2026